EXCLUSIVES
FacebookTwitterLinkedInGoogle+RSS Feed
Fire EMSEMS TodayEMS Insider

Microbubbles Deliver Blood-Clot Busting Drugs to Patients

CHICAGO -- Physicians announced today that tiny microbubbles are being used to more effectively deliver a blood clot busting drug to patients while they are in the ambulance during acute heart attack.

"Time is muscle," said Dr. Otto Kamp from VU University Medical Center in the Netherlands, stating that the quicker you deliver therapy the more heart muscle you will save.

Liquid suspensions of tiny gas microbubbles have traditionally been used as a diagnostic imaging tool. The microbubble suspensions are routinely used as ultrasound contrast agents to improve the clarity and reliability of an ultrasound image without exposing patients to ionizing radiation. The microbubbles are about a third the size of a red blood cell and, when they are injected into a patient's arm vein, they improve the clarity and accuracy of diagnostic ultrasound exams. The microbubbles are expelled from the body within minutes.

Dr. Kamp's findings move microbubbles from a diagnostic imaging use to an exciting therapeutic application. He used microbubblesalong with TPA, a drug that busts blood clots.When theinjected microbubbles reached the clot, increased ultrasound frequencies were applied to cause the microbubbles to burst. The burst bubbles create tiny holes in the clot,allowing the drug to workmore effectively in itstargeted location.

"This permits a lower and safer dose of TPA with reduced side effects, especially hemorrhage and stroke," according to Dr. Kamp. "This also permits increased doses of TPA and improves the efficiency of this therapy."

Steve Feinstein, a Rush University cardiologist and ICUS Co-president, said the findings demonstrate the vast potential benefits of using microbubble ultrasound contrast agents as a platform for delivering a range of drugs and genes to specific organ systems and tumors.

"Considerable work is underway showing that microbubbles may be useful in delivering cancer drugs, diabetes drugs, and genes that increase HDL -- good cholesterol -- to targeted sites throughout the body," he said. "Dr. Kamp's work is especially exciting because it now showshow a related technique works in patients."

The Netherlandsresearch was announced at the 27th Annual Advances in Contrast Ultrasound ICUS Bubble Conference, a gathering of physcians and scientists around the world in the fields of cardiology, radiology, vascular medicine, gastro-intestinal medicine, oncology, and other medical specialties.

ABOUT ICUS: ICUS is an international, multi-disciplinary, not-for-profit medical society that is exclusively dedicated to advancing the use of contrast enhanced ultrasound diagnostic imaging to improve patient care worldwide. Founded in September 2008, ICUS brings together physicians, scientists, and other ultrasound imaging professionals from over 55 countries. ICUS members represent diverse specialties such as cardiology, radiology, vascular imaging, gastro-intestinal imaging, oncology, OB-GYN, and hepatology. For more information about ICUS, please visit www.icus-society.org/2013site .



RELATED ARTICLES

Over 40 Missing as Flood Waters Rise in Texas

Firefighters in Houston carried out over 500 water rescues.

Colorado River Fire Rescue Saves 100 Hours a Month After Implementing Aladtec’s Workforce Management System for Public Safety

The three days a week this agency saves is now focused on community outreach.

Twister Kills 13 in Mexico Border City

Tornado strikes city on U.S. – Mexico border destroying homes.

Waterspout Sends Florida Bounce House Flying, Children Injured

Three children were injured when a waterspout sent a bounce house flying.

12 Missing After Storm, Flooding Hit Texas

Rescue teams search for members of two families after home is swept off its foundation.

Bull Riders See Little Change in Concussion Prevention

Medical staffer sees no drop in numbers despite helmet use.

Features by Topic

Featured Careers

 

JEMS TV

FEATURED VIDEO TOPICS

Learn about new products and innovations featured at EMS Today 2015

 

JEMS Connect

CURRENT DISCUSSIONS

 
 

EMS BLOGS

Blogger Browser

Today's Featured Posts