Microbubbles Deliver Blood-Clot Busting Drugs to Patients

Research shows they can more effectively and quickly deliver drugs to patients while they're in the ambulance during acute heart attack


 
 

Business Wire | | Friday, September 21, 2012


CHICAGO -- Physicians announced today that tiny microbubbles are being used to more effectively deliver a blood clot busting drug to patients while they are in the ambulance during acute heart attack.

"Time is muscle," said Dr. Otto Kamp from VU University Medical Center in the Netherlands, stating that the quicker you deliver therapy the more heart muscle you will save.

Liquid suspensions of tiny gas microbubbles have traditionally been used as a diagnostic imaging tool. The microbubble suspensions are routinely used as ultrasound contrast agents to improve the clarity and reliability of an ultrasound image without exposing patients to ionizing radiation. The microbubbles are about a third the size of a red blood cell and, when they are injected into a patient's arm vein, they improve the clarity and accuracy of diagnostic ultrasound exams. The microbubbles are expelled from the body within minutes.

Dr. Kamp's findings move microbubbles from a diagnostic imaging use to an exciting therapeutic application. He used microbubblesalong with TPA, a drug that busts blood clots.When theinjected microbubbles reached the clot, increased ultrasound frequencies were applied to cause the microbubbles to burst. The burst bubbles create tiny holes in the clot,allowing the drug to workmore effectively in itstargeted location.

"This permits a lower and safer dose of TPA with reduced side effects, especially hemorrhage and stroke," according to Dr. Kamp. "This also permits increased doses of TPA and improves the efficiency of this therapy."

Steve Feinstein, a Rush University cardiologist and ICUS Co-president, said the findings demonstrate the vast potential benefits of using microbubble ultrasound contrast agents as a platform for delivering a range of drugs and genes to specific organ systems and tumors.

"Considerable work is underway showing that microbubbles may be useful in delivering cancer drugs, diabetes drugs, and genes that increase HDL -- good cholesterol -- to targeted sites throughout the body," he said. "Dr. Kamp's work is especially exciting because it now showshow a related technique works in patients."

The Netherlandsresearch was announced at the 27th Annual Advances in Contrast Ultrasound ICUS Bubble Conference, a gathering of physcians and scientists around the world in the fields of cardiology, radiology, vascular medicine, gastro-intestinal medicine, oncology, and other medical specialties.

ABOUT ICUS: ICUS is an international, multi-disciplinary, not-for-profit medical society that is exclusively dedicated to advancing the use of contrast enhanced ultrasound diagnostic imaging to improve patient care worldwide. Founded in September 2008, ICUS brings together physicians, scientists, and other ultrasound imaging professionals from over 55 countries. ICUS members represent diverse specialties such as cardiology, radiology, vascular imaging, gastro-intestinal imaging, oncology, OB-GYN, and hepatology. For more information about ICUS, please visit www.icus-society.org/2013site .



Copyright © 2013 LexisNexis, a division of Reed Elsevier Inc. All rights reserved. Terms and Conditions | Privacy Policy


Connect: Have a thought or feedback about this? Add your comment now
Related Topics: News, microbubbles, blood clots

What's Your Take? Comment Now ...

Featured Careers & Jobs in EMS





 

Get JEMS in Your Inbox

 

Fire EMS Blogs


Blogger Browser

Today's Featured Posts

 

EMS Airway Clinic

Innovation & Progress

Follow in the footsteps of these inspirational leaders of EMS.
More >

Multimedia Thumb

NAEMT: Transforming EMS

A look inside at the Mobile Healthcare Paramedic system.
Watch It >


Multimedia Thumb

Austin-Travis County Community Health Paramedic Program

Overview of program provides operation and referral details.
Watch It >


Multimedia Thumb

Flight Paramedic’s Perfect Weekend

Carilion Lifeguard Flight Paramedic shares what would make his perfect weekend.
Watch It >


Multimedia Thumb

Honolulu EMS Pilot Program

New program tests change in shift schedule for EMTs and Paramedics.
Watch It >


Multimedia Thumb

Numerous Rescues during Arizona Flooding

Severe flooding across the region prompted several rescues.
More >


Multimedia Thumb

Colorado Hiker Rescue

Injured hiker spent three hours in a crevice.
More >


Multimedia Thumb

Airlift at Swiss Train Derailment

Helicopters used to help reach the injured.
More >


Multimedia Thumb

Field Bridge Xpress ePCR on iPad, Android, Kindle Fire

Sneak peek of customizable run forms & more.
Watch It >


Multimedia Thumb

LMA MAD Nasal™

Needle-free intranasal drug delivery.
Watch It >


Multimedia Thumb

Braun Ambulances' EZ Door Forward

Helps to create a safer ambulance module.
Watch It >


More Product Videos >