Meridian Introduces Single-Vial Dose of CYANOKIT

Now with a longer shelf life

 

 
 
 

| Wednesday, November 2, 2011


Meridian Medical Technologies, Inc., a Pfizer company, has introduced a new single-vial dose of CYANOKIT® (hydroxocobalamin for injection) 5 g. In this new presentation of CYANOKIT®, the entire starting dose of 5 g hydroxocobalamin is now provided in a single vial, replacing the previous kit containing two, 2.5-g vials. CYANOKIT® is approved by the U.S. Food and Drug Administration for the treatment of either known or suspected cyanide poisoning.[i]
Cyanide (CN) can be released by virtually any material containing carbon and nitrogen when burned under high temperature and low oxygen conditions.[ii],[iii] There is high potential for CN toxicity at many fire scenes due to the increased use of synthetic materials that produce CN during combustion in closed-space fires.2,3 Moderate to high concentrations of cyanide can cause severe injury and death within minutes.[iv] Therefore Cyanide poisoning is a life-threatening situation that requires immediate medical attention.
There’s currently no diagnostic test to confirm CN poisoning in the field within the limited window for initiating potentially lifesaving intervention.2,3 In addition, CN poisoning can be difficult to differentiate with carbon monoxide (CO) poisoning due to common signs and symptoms.2 Because CN poisoning prevents cells from using oxygen (O2), signs and symptoms of CN poisoning also mimic those of O2 deprivation.[v]
Cyanide poisoning may result from inhalation, ingestion, or dermal exposure and should be suspected in smoke inhalation victims if they’re exposed to fire or smoke in an enclosed area, present with soot around the mouth, nose, or back of mouth or have an altered mental status.
CYANOKIT® is administered intravenously after being reconstituted with sodium chloride for injection. Hydroxocobalamin, the main component in CYANOKIT®, strongly binds the cyanide directly, forming a natural form of vitamin B12, cyanocobalamin, which is excreted in the urine.4
In addition to the full starting dose of CYANOKIT® 5 g now contained in a single vial, the new packaging is more compact than the previous packaging and the new dose also features a 20 percent greater shelf life (36 months from the date of formulation).
To learn more about CYANOKIT®, please visit www.CYANOKIT.com.

[i] Cyanokit [package insert]. Columbia, MD: Meridian Medical Technologies, Inc.; 2011.
[ii] Agency for Toxic Substances and Disease Registry. Cyanide toxicity. Am Fam Physician. 1993;48(1):107-114.
[iii] Alcorta R. Smoke inhalation & acute cyanide poisoning. In: Losavio K, ed. Smoke Inhalation & Hydrogen Cyanide Poisoning. San Diego, CA: JEMS Communications; 2004:6-17.
[iv] Eckstein M, Maniscalco PM. Focus on smoke inhalation— the most common cause of acute cyanide poisoning. Prehosp Disaster Med. 2006;21(2):s49-s55.
[v] Schnepp R. Where there’s fire—there’s smoke! In: Smoke: Cyanide and Carbon Monoxide: The Toxic Twins of Smoke Inhalation. Indianapolis, IN: Cyanide Poisoning Treatment Coalition; 2009:3-8

 




Connect: Have a thought or feedback about this? Add your comment now
Related Topics: News, Industry News

 
What's Your Take? Comment Now ...

Buyer's Guide Featured Companies

Featured Careers & Jobs in EMS

Get JEMS in Your Inbox

 

Fire EMS Blogs


Blogger Browser

Today's Featured Posts

 

EMS Airway Clinic

Mechanical CPR is Producing Resuscitation Results Beyond Expectations

Discover why clinical studies are finding mechanical CPR just as effective as optimally-performed CPR.
More >

Multimedia Thumb

New York First Responders Take Extraordinary Steps to Help Residents

Snow causes fire and EMS crews to go beyond call of duty.
Watch It >


Multimedia Thumb

Raw Video: Explosion and Fire at California Business

Over a dozen hurt in Santa Paula blaze.
Watch It >


Multimedia Thumb

Four Workers Killed at Texas Chemical Plant

Five employees exposed to methyl mercaptan in La Porte.
Watch It >


Multimedia Thumb

Worker Killed in North Carolina Bridge Collapse

A fatal construction site collapse occurred in Wake County.
Watch It >


Multimedia Thumb

Plane Crashes into Chicago Home

Pilot reported engine trouble after takeoff.
More >


Multimedia Thumb

Switzerland Landslide Kills Two, Injures Four

Slide hits residential building near Lugano.
More >


Multimedia Thumb

World Trade Center Rescue

Technical rescue work is done at nation’s tallest skyscraper.
More >


Multimedia Thumb

VividTrac offered by Vivid Medical - EMS Today 2013

VividTrac, affordable high performance video intubation device.
Watch It >


Multimedia Thumb

Field Bridge Xpress ePCR on iPad, Android, Kindle Fire

Sneak peek of customizable run forms & more.
Watch It >


Multimedia Thumb

LMA MAD Nasal™

Needle-free intranasal drug delivery.
Watch It >


More Product Videos >